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In more complex analysis situations, complete cases analysis could introduce bias to the parameter estimates In short, we do not side with those who argue that complete cases analysis should not be used because of the potential for bias Rather, we argue that complete cases analysis should not be used because of loss of statistical power In virtually all research situations, using complete cases analysis means that the researcher must discard at least some information In fact, it is becoming more and more common that a large proportion of cases is lost if listwise deletion is used In order to illustrate this issue, consider two proportions: the proportion of complete cases, and the proportion of nonmissing data points.

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The latter gure is calculated easily by considering the total number of data points in a data set, N k, where N is the number of cases and k is the number of variables One can simply divide the number of nonmissing data points by N k to determine the proportion of nonmissing data points Of course, if most of the data points are missing, the results may be suspect regardless of the analysis used However, there are many situations in which the proportion of nonmissing data points is actually quite high but the proportion of complete cases is disturbingly low.

Three common research situations can produce this pattern: (a) missing data on different variables in different cases; (b) a substantial amount of missing data in one part of a model, with very little missing data in other parts of the model; and (c) planned missing data designs such as the three-form design (Graham et al, 1994, 1996, Graham, Taylor, et al, 2001) In sum, we argue that complete cases should not be used as the general analysis strategy Although bias may be minimal in many research situations, the loss of power could be tremendous However, we explicitly stop short of saying that complete cases analysis should never be used First, we have.

CHAPTER 6 6.3 (a) 0.237, (b) 3.75 6.5 0.611, 4.2 m X n 6.8 (a) 1 pk (1 p)n k k k 0 n n X (b) (k m) pk (1 p)n k k k m 1 6.10 0.584 s r 1 X k 1 6.12 pr (1 p)k r r 1 k r 6.14 6.17 6.26 6.28 6.30 0.096 (a) 0.349, (b) 5 0.93 1:4 10 24 pX (k) 22:5k e 22:5 /k3, k 0, 1, 2, F F F v k t exp ( tv /w) 6.32 pk (0, t) , k 0, 1, 2, F F F k3 w

1 Proof: 0 p(x) 1 implies that log p(x) 0.

obtained a bachelor s degree in a social science such as psychology or sociology and subsequently entered a two-year graduate program to attain their master s degree in social work (MSW). Next, they must complete up to two years of supervised clinical experience (depending on the state) to become a Licensed Clinical Social Worker, or LCSW. Similar to the clinical psychology internship, many social workers receive training in psychotherapy and psychiatric diagnoses during their year or years of supervised clinical experience. Unlike psychology they generally do not obtain extensive training in conducting research or using psychological testing instruments. However, those who earn a doctorate degree in social work (DSW) often are interested in research and academic careers. Historically, social workers focused on patient case management (i.e., helping the patient get the most out of his or her inpatient or outpatient treatment and helping patients transition to work or further treatment following discharge), patient advocacy, and a liaison to optimal social service agencies and benefits. Whereas psychiatrists have historically focused on biological theories and interventions and psychologists have focused on psychological theories and intervention, social workers have focused on social theories and interventions. Today, social workers can conduct psychotherapy with individuals, families or groups, or undertake administrative roles within agencies, hospitals, or social service settings. Providing direct clinical services to clients and patients is the most frequently reported activity of social workers (National Association of Social Workers, 2003). Social workers can be employed in numerous settings including schools, hospitals, clinics, and private practice. Employment in social service agencies and both inpatient and outpatient health facilities are the most common settings for social workers while about 12% are engaged in private practice (National Association

Mitomycin C: 8 g/ml in DMEM. Care should be taken when handling the powdered form of mitomycin. Use a syringe to add 5 ml of DMEM to the closed bottle of mitomycin by puncturing the top. Once mitomycin is resuspended in the bottle, use the syringe to draw the DMEM and mitomycin out of the bottle, and then dilute it to 8 g/ml in DMEM and sterilize with a 0.22- m low-protein-binding lter. Aliquot and freeze at 20 C until needed. Collagenase type IV: 200 units of collagenase per ml of DMEM, ltered through a 0.22- m lter. Solution can be used for up to 2 weeks. Trypsin, 0.5% in PBSA.

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